Alison Mosshart, Wild Beasts and Animal Collective have all urged the BBC not to close down 6 Music.
The digital radio station has been outlined for closure, along with Asian Network, in an effort to cut costs.
The artists, who are all attached to independent record label Domino, argue that 6 Music is crucial for the future of new music.
“Please don't leave us musicians and music lovers with such a void,” Mosshart, who fronts The Kills and The Dead Weather, said.
“We need BBC6. It is the only radio station we all listen too, and seemingly, the only station that plays anything worth listening too.”
US born Mosshart added that the closure of 6 Music would be “culturally damaging” and would likely stop her from listening to English radio.
Wild Beasts singer Hayden Thorpe said: “I'm in no doubt the unrelenting support we have had from BBC6 has massively helped our career.
“This sends out a damning message to creative young people.”
Meanwhile, Animal Collective's Noah Lennox said 6 Music should be saved because it offered “unpredictable radio”.
The BBC's plans to close 6 Music have led to a widespread backlash from figures within the music industry and the wider public.
BBC Director General Mark Thompson said last week that the earliest 6 Music and Asian Network would close would be the end of 2011.
You can keep up to date with all the latest news from Gigwise by following us on Twitter and liking us on Facebook.

Elton John hospitalised with 'serious repiratory infection'
Lady Gaga 'won't change shows' after protests
Rihanna performs new single on American Idol - watch
Bruce Springsteen debuts 'Rocky Ground' video - watch
Kate Moss and Kristen Stewart planning Kills duet?
The Kills: The Making Of 'The Last Goodbye' Video
The Kills' 'The Last Goodbye' Video Directed By Actress Samantha Morton - Watch
The hottest WAGs of rock and roll
The Enemy take 'Streets In The Sky' to Manchester
Who's tatt is that? Guess the rockstar from their body work